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- Nicole Osier and C Edward Dixon.
- Safar Center for Resuscitation Research, University of Pittsburgh, 201 Hill Building, 3434 Fifth Avenue, Pittsburgh, PA, 15213, USA.
- Methods Mol. Biol. 2016 Jan 1; 1462: 177-92.
AbstractControlled cortical impact (CCI) is a commonly used and highly regarded model of brain trauma that uses a pneumatically or electromagnetically controlled piston to induce reproducible and well-controlled injury. The CCI model was originally used in ferrets and it has since been scaled for use in many other species. This chapter will describe the historical development of the CCI model, compare and contrast the pneumatic and electromagnetic models, and summarize key short- and long-term consequences of TBI that have been gleaned using this model. In accordance with the recent efforts to promote high-quality evidence through the reporting of common data elements (CDEs), relevant study details-that should be reported in CCI studies-will be noted.
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