• Methods Mol. Biol. · Jan 2012

    Cocaine self-administration in rats: discrete trials procedures.

    • Carson V Dobrin and David C S Roberts.
    • Neuroscience Program, Wake Forest University Health Sciences, Winston-Salem, NC, USA. cdobrin@wfubmc.edu
    • Methods Mol. Biol. 2012 Jan 1; 829: 291-302.

    AbstractA discrete trials procedure involves splitting up a self-administration session so that there are multiple distinct trials and inter-trial-intervals. This schedule is well suited to be used over 24 h periods which allows insight into diurnal variability in self-administration behavior. DT is also well suited for investigations using pretreatments for increasing or decreasing both high and low probability behavior.

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