• Hideaki Miyamoto, Atsuo Morio, Hiroshi Izumi, Akio Yamazaki, Zumin Wang, Toshiroh Futagawa, and Satoshi Sonobe.
• Department of General Thoracic Surgery, Juntendo University, School of Medicine, 2-1-1, Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. miyagen@med.juntendo.ac.jp
• Anticancer Res. 2003 Sep 1; 23 (5b): 4153-6.

BackgroundWe measured thymidylate synthase (TS) activity, dihydropyrimidine dehydrogenase (DPD) activity and TS inhibition rate (TSIR) in tumor tissue and lymph node metastasis, considered predictors of response to DIFs, in patients with lung cancer.Patients And MethodsFourteen patients with non-small cell lung cancer (NSCLC) were given UFT for 1-2 weeks before surgery. Total TS activity (total TS), TSIR and DPD activity were measured in tumors, lymph node metastases and normal lung and lymph nodes.ResultsTotal TS activity and DPD activity were significantly higher in lung tumors than in normal lung (TS, p = 0.0225; DPD, p < 0.0001). Total TS activity was slightly but not significantly higher in lymph node metastases than in normal lymph nodes. DPD activity and TSIR were similar in the other tissues.ConclusionAfter preoperative treatment with UFT, TS and DPD activities are significantly higher in lung tumor tissue than in normal lung tissue in patients with NSCLC.

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