• Ana Paula Dantas Ribeiro, Amanda Gomes Pereira, Márcia Cristina Todo, Anderson Seiji Soares Fujimori, Priscila Portugal Dos Santos, Danielle Dantas, Ana Angélica Fernandes, Silmeia Garcia Zanati, Neuza Mariko Aymoto Hassimotto, Leonardo Antônio Mamede Zornoff, Paula Schmidt Azevedo, Marcos Ferreira Minicucci, PaivaSergio A RSARInternal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil., and Bertha Furlan Polegato.
• Internal Medicine Department, Botucatu Medical School, São Paulo State University (UNESP), Botucatu, Brazil.
• Nutrition. 2021 Nov 1; 91-92: 111350.

ObjectivesDoxorubicin is a highly effective chemotherapeutic agent for treating several types of cancer; however, it can induce cardiotoxicity. We evaluated the influence of Pera and Moro orange juices on cardiac remodeling induced by acute administration of doxorubicin in rats.MethodsWe allocated 120 male Wistar rats into six groups: control (C), Pera orange juice (PO), Moro orange juice (MO), doxorubicin (D), doxorubicin + Pera orange juice (DPO), and doxorubicin + Moro orange juice (DMO). Groups PO and DPO received Pera orange juice, MO and DMO received Moro orange juice, and C and D received water with maltodextrin (100 g/L) for 4 wk. Subsequently, groups D, DPO, and DMO received 20 mg/kg doxorubicin and C, PO, and MO received saline. Echocardiogram and euthanasia were performed 48 h after doxorubicin injection. Juice and animal-serum flavonoid identification and quantification were evaluated by liquid chromatography/electrospray ionization multistage mass spectrometry. Oxidative stress and myocardial metabolism were evaluated by spectrophotometry.ResultsSystolic and diastolic left ventricular dysfunction increased oxidative stress and pathologic changes in myocardial energy metabolism of rats treated with doxorubicin. Intake of both orange juices improved left ventricular function, decreased oxidative stress, and attenuated the myocardial energy metabolism changes. Moro orange juice had a more pronounced effect than Pera orange juice in glutathione peroxidase activity, citrate synthase, and β-hydroxyacyl-CoA dehydrogenase activity.ConclusionsPera and Moro orange juices attenuated cardiac remodeling induced by doxorubicin, improved myocardial energy metabolism, and attenuated oxidative stress. However, Moro orange juice was more effective than Pera orange juice in modifying energy metabolism.Copyright © 2021 Elsevier Inc. All rights reserved.

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