• G K Lighthall, M A Jamieson, J Katolik, and J G Brock-Utne.
• Department of Anesthesia, Stanford University School of Medicine, CA 94305, USA.
• J Clin Anesth. 1999 May 1;11(3):220-5.

Study ObjectiveTo determine the onset and clinical duration of cisatracurium and rocuronium in equipotent doses in balanced opioid/isoflurane anesthesia.DesignRandomized, controlled study.SettingUniversity hospital.Patients40 healthy patients scheduled for elective surgery.InterventionsPatients underwent anesthesia induction with thiopental or propofol with a cisatracurium intubating dose of either 0.15 or 0.2 mg/kg or a rocuronium dose of either 0.9 or 1.2 mg/kg. These doses correspond to three and four times the ED95 dose.Measurements And Main ResultsThe onset time and time to 25% recovery of baseline first twitch in a train-of-four were determined using an accelerometric sensor. Rocuronium had a faster onset time that cisatracurium at equipotent doses (3 x ED95: 134 vs. 220 sec respectively, and at 4 x ED95: 95 vs. 162 sec). Recovery tended to be faster, but not statistically different for cisatracurium compared to rocuronium.ConclusionsWith equipotent intubating doses of rocuronium and cisatracurium, rocuronium produces a more rapid onset of muscle relaxation. The data suggest a tendency toward more rapid clinical recovery of cisatracurium compared to equipotent doses of rocuronium, although these differences were not statistically significant.

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