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Hematol. Oncol. Clin. North Am. · Oct 2019
ReviewImpact of Novel Monoclonal Antibody Therapeutics on Blood Bank Pretransfusion Testing.
- Zhen Mei and Geoffrey D Wool.
- University of Chicago Medicine, 5841 South Maryland Avenue, AMB S339, MC 3083, Chicago, IL 60637, USA.
- Hematol. Oncol. Clin. North Am. 2019 Oct 1; 33 (5): 797-811.
AbstractNovel monoclonal antibody therapies are increasing in number and clinical significance as their role in oncologic formularies expands. Anti-CD38 and anti-CD47/SIRPα agents commonly interfere with pretransfusion compatibility testing. Anti-CD38 interference is mitigated by dithiothreitol, which disrupts CD38 antigen on reagent red cells; however, this modification limits rule-out of all clinically significant antibodies. Several anti-CD47 agents are in clinical trials and demonstrate wide variability in pretransfusion testing interference. Modifications to pretransfusion testing can limit interference by anti-CD47 agents. Rapid dissemination of knowledge of these monoclonal antibody agents to the broader transfusion medicine community is paramount for continued patient transfusion safety.Copyright © 2019 Elsevier Inc. All rights reserved.
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