Hematology/oncology clinics of North America
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Hematol. Oncol. Clin. North Am. · Oct 2019
ReviewImpact of Novel Monoclonal Antibody Therapeutics on Blood Bank Pretransfusion Testing.
Novel monoclonal antibody therapies are increasing in number and clinical significance as their role in oncologic formularies expands. Anti-CD38 and anti-CD47/SIRPα agents commonly interfere with pretransfusion compatibility testing. ⋯ Modifications to pretransfusion testing can limit interference by anti-CD47 agents. Rapid dissemination of knowledge of these monoclonal antibody agents to the broader transfusion medicine community is paramount for continued patient transfusion safety.