• Naila Abdul Sattar, Sumera Shaheen, Fatma Hussain, and Amer Jamil.
• Department of Bio-Chemistry, Government College Women University, Faisalabad-38000.
• Afr Health Sci. 2021 Mar 1; 21 (1): 8-14.

BackgroundNumerous diabetes susceptibility loci, include a region consisting vitamin D receptor gene found in chromosome 12q, have been known using genome wide screens.AimThe aim of present study is to probe the relationship between polymorphism of vitamin D receptor gene (single nucleotide polymorphisms) and type 2 diabetes mellitus (T2DM). Five hundred T2DM patients and 200 healthy subjects with normal HbA1c (≤ 5.0 %), fasting blood sugar (≤ 120 mg/dL) and random blood sugar (≤ 140 mg/dL) were enrolled.MetholodgyThe genotypes were found by polymerase chain reaction restriction fragment length polymorphism and DNA sequencing.Resultsrevealed that no considerable differences in frequencies of genotype and allele of the Bsm I and Fok I polymorphisms between healthy and patients in the North England (For Fok I: OR = 1.11, 95% CI: 0.72-1.12; for Bsm I: OR = 1.35, 95% CI: 0.79-1.98).ConclusionIt is recommended that both following polymorphisms of vitamin D receptor gene may not considerably add to the progression of T2DM in the North England.© 2021 Sattar NA et al.

25 keywords...

hide…