• Olusola A Sogebi, Bolanle O Adefuye, and Ebenezer A Ajayi.
• Department of Surgery, Faculty of Clinical Sciences, OACHS, Olabisi Onabanjo University, Sagamu, Nigeria.
• Afr Health Sci. 2021 Mar 1; 21 (1): 230-237.

BackgroundHearing threshold changes occurred relative to baseline at both one and two weeks after onset of aminoglycoside therapy.ObjectivesTo assess changes in audiometric hearing thresholds between pre-treatment values and two weeks into therapy. To document observed changes, and occurrence of ototoxicity within the period.MethodsProspective analytical cohort study on drug-resistant tuberculosis patients. Basic demographic parameters were taken. Three-point audiometric assessments within two weeks into therapy were done. Percentage of patients with ototoxicity were calculated. Pure tone threshold changes between the three audiometric values were compared.ResultsAudiograms of 53 patients comprising 56.6% males; age range was 13 to 91 years. Both air and bone conduction hearing thresholds significantly worsened between baseline and one week into therapy (p=0.011, and 0.015 respectively), and between baseline and two weeks into therapy (p=0.003 and 0.042 respectively). Minimal insignificant reduction occurred between both air and bone conduction hearing values of week 1 and week 2 of therapy (p= 1.000 and 0.856 respectively). By audiometric criteria, 4 patients (7.5%) developed ototoxicity within two weeks of treatment.ConclusionAudiometric assessments within two weeks into therapy with anti-tuberculous therapy may not represent baseline audiometry. 7.5% of the patients developed ototoxicity within two weeks of therapy.© 2021 Sogebi OA et al.

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