• Ann Pharmacother · Mar 1996

    Case Reports

    Suspected neuroleptic malignant syndrome in a patient receiving clozapine.

    • L Ganelin, P S Lichtenberg, E L Marcus, and R G Munter.
    • Department of Psychiatry, Herzog Hospital, Jerusalem, Israel.
    • Ann Pharmacother. 1996 Mar 1; 30 (3): 248-50.

    ObjectiveTo report a case of suspected neuroleptic malignant syndrome (NMS) associated with clozapine therapy.Case SummaryA 42-year-old schizophrenic man treated with clozapine developed a temperature of 39.5 degrees C, diaphoresis, tachycardia, rigidity, and leukocytosis. His serum creatine kinase concentration was 25 000 U/L. A diagnosis of NMS was made. He was treated with bromocriptine and supportive therapy, and recovered within a week.DiscussionDespite earlier expectations that clozapine, with a pharmacologic profile differing from that of other antipsychotic medications, might not cause NMS, NMS remains the most likely diagnosis in this case.ConclusionsNMS may be a possible complication of clozapine therapy.

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