• Robert DuBroff and Maryanne Demasi.
• Division of Cardiology, Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address: rjdabq@gmail.com.
• Prev Med. 2021 Dec 1; 153: 106791.

AbstractOver the past 10 years cholesterol levels have been falling while the number of Americans dying of heart disease has been steadily climbing. This apparent paradox compels us to question whether lowering cholesterol is the best way to prevent coronary heart disease. A number of recent studies suggest that cholesterol, specifically LDL-C, may not be a primary risk factor for coronary heart disease and other markers, such as insulin resistance or remnant cholesterol, may be much more important. Furthermore, therapies designed to prevent coronary heart disease by lowering cholesterol with drugs or diet have yielded inconsistent results. Despite the widespread utilization of cholesterol-lowering statins in Europe, observational studies indicate that there has been no accompanying decline in coronary heart disease deaths. This new evidence should give us pause as we try to understand why the campaign to prevent heart disease by lowering cholesterol has not achieved its goals.Copyright © 2021 Elsevier Inc. All rights reserved.

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