• Lin Chunlei, Ye Qian, Qu Yundong, Wang Lei, Liu Jiaye, and Li Tao.
• Department of Infectious Diseases and Hepatolgy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
• J Coll Physicians Surg Pak. 2021 Oct 1; 31 (10): 1168-1173.

ObjectiveTo describe the baseline characteristics and two-year outcomes of patients with Child-Pugh grades A and B cirrhosis; and evaluate the predictive value of liver stiffness for the development of adverse outcomes (AOs) in this patient population.Study DesignA prospective cohort study.Place And Duration Of StudyThe Second Hospital, Cheeloo College of Medicine, Shandong University, China between September 2018 and March 2021.MethodologyThe present study consecutively included patients with Child-Pugh grades A and B cirrhosis. Patients were followed up every six months until two years. Baseline demographic characteristics and laboratory indexes were collected. Liver stiffness and controlled attenuation parameter were measured at baseline, month 6 and month 12. The observational endpoint was AOs, including liver-related patient death and hepatocellular carcinoma (HCC).ResultsA total of 174 patients were included in the final cohort. Hepatitis B virus (HBV)-induced liver cirrhosis accounted for the vast majority of enrolled cases (82.2%). AOs were observed in six patients. Multivariate logistic regression model was performed and liver stiffness was considered as the only independent predictor for AOs (OR 1.071, p = 0.006). Liver stiffness was also significantly improved at 12 months compared with the baseline data (median 10.6 vs. 13.3 kPa, p <0.001).ConclusionPatients with Child-Pugh grades A and B cirrhosis had an acceptable short-term prognosis. Greater liver stiffness predicted two-year AOs in these patients with relatively mild cirrhosis. The prognostic value of changes in liver stiffness warrants further investigation. Key Words: Liver cirrhosis, Child-Pugh score, Liver stiffness, Asian population, Outcome.

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