• Yuanlin Wang, Lanzhong Guo, Jun Jiang, Fangfang Wang, Paul J Hardiman, and Fan Qu.
• Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
• J Coll Physicians Surg Pak. 2021 Oct 1; 31 (10): 1186-1190.

ObjectiveTo evaluate the body mass index and neurologic development of 1-2 years offspring born to mothers with polycystic ovary syndrome.Study DesignA case-control study.Place And Duration Of StudyDongyang Women and Children's Hospital, Zhejiang Province, China, between June 2018 and January 2019.MethodologyA total of 145 children were included in the final analysis, including 16 daughters of mothers with PCOS, 13 sons of mothers with PCOS, 55 daughters of mothers without PCOS and 61 sons of mothers without PCOS. Developmental assessments for each child were conducted, including anthropometric measurements and ability developments using the Denver developmental screening test.ResultsThe body mass index of children was significantly lower in polycystic ovary syndrome group than control group (p=0.022). Children of mothers with polycystic ovary syndrome and control group had no significant differences in the outcomes of the Denver developmental screening test (all p >0.05).ConclusionMaternal polycystic ovary syndrome may affect body mass index of offspring aged 1-2 years and had no negative effects on neurologic development. However, this conclusion may be limited due to the small sample size. Key Words: Neurologic development, Polycystic ovary syndrome, Offspring, Denver development screening test, Body mass index.

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