• Colin Watts and Nader Sanai.
• Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge, Cambridge, UK. Electronic address: cw209@cam.ac.uk.
• Handb Clin Neurol. 2016 Jan 1; 134: 51-69.

AbstractNeurosurgical intervention remains the first step in effective glioma management. Mounting evidence suggests that cytoreduction for low- and high-grade gliomas is associated with a survival benefit. Beyond conventional neurosurgical principles, an array of techniques have been refined in recent years to maximize the effect of the neurosurgical oncologist and facilitate the impact of subsequent adjuvant therapy. With intraoperative mapping techniques, aggressive microsurgical resection can be safely pursued even when tumors occupy essential functional pathways. Other adjunct techniques, such as intraoperative magnetic resonance imaging, intraoperative ultrasonography, and fluorescence-guided surgery, can be valuable tools to safely reduce the tumor burden of low- and high-grade gliomas. Taken together, this collection of surgical strategies has pushed glioma extent of resection towards the level of cellular resolution. © 2016 Elsevier B.V. All rights reserved.

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