• Mayo Clinic proceedings · Oct 2014

    Observational Study

    Prospective cohort study of the effectiveness of smoking cessation treatments used in the "real world".

    • Daniel Kotz, Jamie Brown, and Robert West.
    • Department of Family Medicine, CAPHRI School for Public Health and Primary Care, Maastricht University Medical Centre, Maastricht, The Netherlands; Cancer Research UK Health Behaviour Research Centre, University College London, London, United Kingdom. Electronic address: d.kotz@maastrichtuniversity.nl.
    • Mayo Clin. Proc. 2014 Oct 1; 89 (10): 136013671360-7.

    ObjectiveTo estimate the "real-world" effectiveness of commonly used aids to smoking cessation in England by using longitudinal data.Patients And MethodsWe conducted a prospective cohort study in 1560 adult smokers who participated in an English national household survey in the period from November 2006 to March 2012, responded to a 6-month follow-up survey, and made at least 1 quit attempt between the 2 measurements. The quitting method was classified as follows: (1) prescription medication (nicotine replacement therapy [NRT], bupropion, or varenicline) in combination with specialist behavioral support delivered by a National Health Service Stop Smoking Service; (2) prescription medication with brief advice; (3) NRT bought over the counter; (4) none of these. The primary outcome measure was self-reported abstinence up to the time of the 6-month follow-up survey, adjusted for key potential confounders including cigarette dependence.ResultsCompared with smokers using none of the cessation aids, the adjusted odds of remaining abstinent up to the time of the 6-month follow-up survey were 2.58 (95% CI, 1.48-4.52) times higher in users of prescription medication in combination with specialist behavioral support and 1.55 (95% CI, 1.11-2.16) times higher in users of prescription medication with brief advice. The use of NRT bought over the counter was associated with a lower odds of abstinence (odds ratio, 0.68; 95% CI, 0.49-0.94).ConclusionPrescription medication offered with specialist behavioral support and that offered with minimal behavioral support are successful methods of stopping cigarette smoking in England.Copyright © 2014 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

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