• Tingjing Zhang, Sabina Rayamajhi, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Yawen Wang, Shunming Zhang, Xuena Wang, Juanjuan Zhang, Huiping Li, Amrish Thapa, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, and Kaijun Niu.
• Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.
• Nutrition. 2022 Jan 1; 93: 111501.

ObjectiveProspective cohort studies linking dietary patterns and hyperuricemia (HUA) are limited, especially in Asian populations. The aim of this study was to prospectively investigate the association between various dietary patterns and risk for HUA in a general adult population.MethodWe used data from the TCLSIH (Tianjin Chronic Low-grade Systemic Inflammation and Health) cohort study of 20 766 men and women who were free from HUA, cancer, and cardiovascular disease at baseline. Dietary patterns at baseline were identified with factor analysis based on responses to a validated 81-item food frequency questionnaire. HUA was defined as serum uric acid levels >420 μmol/L in men and >350 μmol/L in women. Cox proportional hazards regression models were used to examine the association of dietary patterns with incident HUA.ResultsIn all, 4389 first incident cases of HUA occurred during 73 822 person-years of follow-up (median follow-up of 4.2 y). Three main dietary patterns were extracted. They were the vegetable, sweet food, and animal food patterns. After adjusting for demographic characteristics, lifestyle factors, other dietary pattern scores, and inflammatory markers, comparing the highest with the lowest quartiles of dietary pattern scores, the multivariable hazard ratios (95% confidence interval) of HUA were 0.79 (0.72-0.87; Ptrend < 0.0001) for the vegetable pattern, 1.22 (1.12-1.33; Ptrend < 0.0001) for the sweet food pattern, and 1.24 (1.13-1.37; Ptrend < 0.0001) for the animal food pattern.ConclusionsDietary patterns rich in animal or sweet foods were positively associated with a higher risk for HUA, whereas the vegetable pattern was negatively associated.Copyright © 2021 Elsevier Inc. All rights reserved.

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