• J Coll Physicians Surg Pak · Mar 2022

    Neurotrophic Factor Levels and Cognitive Functions before and after the Repetitive Transcranial Magnetic Stimulation in Treatment Resistant Depression.

    • Dudu Demiroz, Ismet Esra Cicek, Huseyin Kurku, and Ibrahim Eren.
    • Department of Psychiatry, Karaman Research and Training Hospital, Karaman, Turkey.
    • J Coll Physicians Surg Pak. 2022 Mar 1; 32 (3): 335-339.

    ObjectiveTo determine relationship between the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) on cognitive impairment and brain derived neurotrophic factor (BDNF), glial cell derived neurotrophic factor (GDNF) levels in treatment resistant depression (TRD).Study DesignDescriptive study.Place And Duration Of StudyPsychiatry Clinic of Konya Beyhekim Training and Research Hospital in Turkey, between June and November 2019.MethodologyThe study included 33 TRD patients and 33 healthy subjects. Patients received a total of 20 sessions of rTMS treatment. Serum BDNF and GDNF levels were measured before and after rTMS treatment. Additionally, the severity of depression as well as cognitive functions were assessed at the baseline and after the treatment.ResultsThe rTMS treatment significantly improved depressive and cognitive symptoms in patients with TRD. Although the level of serum BDNF and GDNF increased after rTMS treatment, it was associated with the improvement in symptoms, but not significantly.ConclusionsrTMS treatment contributes to the antidepressant effect by normalising serum BDNF and GDNF levels in patients with TRD. Adding rTMS to antidepressants is, therefore, an appropriate treatment option for depressive patients with cognitive impairment. Key Words: rTMS, BDNF, GDNF, Cognitive function.

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