• Mohd Rohaizat Hassan, Noor Atika Azit, Suhaiza Mohd Fadzil, Siti Rasidah Abd Ghani, Norfazilah Ahmad, and Azmawati Mohammed Nawi.
• Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, 56000 Cheras, Kuala Lumpur, Malaysia.
• Afr Health Sci. 2021 Sep 1; 21 (3): 112411401124-1140.

BackgroundThe insecticides used widely has led to resistance in the vector and impose a challenge to vector control operation.ObjectivesThis review aims to analyse the distribution of insecticide resistance of dengue vectors in South East Asia and to describe the mechanism of insecticide resistance.MethodsLiterature search for articles published on 2015 to 2019 from PubMed, Scopus and ProQuest was performed. Total of 37 studies included in the final review from the initial 420 studies.ResultsPyrethroid resistance was concentrated on the west coast of Peninsular Malaysia and Northern Thailand and scattered at Java Island, Indonesia while organophosphate resistance was seen across the Java Island (Indonesia), West Sumatera and North Peninsular Malaysia. Organochlorine resistance was seen in Sabah, Malaysia and scattered distribution in Nusa Tenggara, Indonesia. V1016G, S989P, F1269C gene mutation in Aedes Aegypti were associated with Pyrethroid resistance in Singapore and Indonesia. In Malaysia, over-expressed with monooxygenase P450 genes (CYP9J27, CYP6CB1, CYP9J26 and CYP9M4) Glutathione S-transferases, carboxylesterases commonly associated with pyrethroids resistance in Aedes Aegypti and CYP612 overexpressed in Aedes Albopictus. The genetic mutation in A302S in Aedes Albopictus was associated with organochlorine resistance in Malaysia.ConclusionsRotation of insecticide, integration with synergist and routine assessment of resistance profile are recommended strategies in insecticide resistance management.© 2021 Hassan MR et al.

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