• Syed Tasleem Raza, Sachendra P Singh, Saliha Rizvi, Alina Zaidi, Sanchita Srivastava, Arif Hussain, and Farzana Mahdi.
• Department of Biochemistry, Era's Lucknow Medical College and Hospital, Lucknow, India.
• Afr Health Sci. 2021 Sep 1; 21 (3): 116311711163-1171.

BackgroundEndothelial nitric oxide synthase (eNOS) and potassium voltage-gated channel subfamily J member 11 (KCNJ11) could be the candidate genes for coronary artery disease (CAD). This study investigated the relationship of the eNOS (rs1799983) and KCNJ11 (rs5219) polymorphisms with the presence and severity of CAD in the North Indian population.MethodsThis study included 300 subjects, 150 CAD cases and 150 healthy controls. Single nucleotide polymorphism was evaluated by Polymerase chain reaction and Restriction fragment length polymorphism (PCR-RFLP). Analysis was performed by SPSS (version 21.0).ResultsWe observed that KK genotype of KCNJ11E23K (rs5219) polymorphism (P=0.0001) genotypes and K allele (P=0.0001) was found to be a positive risk factor and strongly associated with CAD. In the case of eNOSG894T (rs1799983) there was no association found with CAD.ConclusionThese results illustrate the probability of associations between SNPs and CAD although specific genetic polymorphisms affecting ion channel function and expression have still to be clarified by further investigations involving larger cohorts.© 2021 Raza ST et al.

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