• Ezona E Ntlahla, Mvuyisi Mo Mfengu, Godwill A Engwa, Benedicta N Nkeh-Chungag, and Constance R Sewani-Rusike.
• Department of Human Biology, Faculty of Health Sciences, Walter Sisulu University PBX1, 5117, Mthatha, South Africa.
• Afr Health Sci. 2021 Sep 1; 21 (3): 1172-1184.

BackgroundThough gut permeability has shown to be associated with measures of obesity and hypertension, its relationship with endothelial dysfunction, an early predictor for cardiovascular diseases remains unknown.ObjectiveThis study assessed the relationship between hypertension, measures of obesity, gut permeability and endothelial dysfunction.MethodsA cross-sectional quantitative study which enrolled 151 South African youths was conducted. Anthropometric and blood pressure measurements were performed. Zonulin, a marker for gut permeability; adiponectin, an anti-inflammatory molecule, as well as asymmetric dimethylarginine (ADMA) and Nitric oxide (NO) which are markers for endothelialfunction were assayed.ResultsApproximately eighteen percent (17.88%) of the participants were hypertensive while 40.4% were pre-hypertensive. Adiponectin significantly increased in hypertensive subjects and negatively correlated (p<0.05) with measures of obesity but was not associated with gut permeability and endothelial dysfunction. Increased body mass index (BMI) and visceral fat (VF) predicted reduced adiponectin (inflammation). Zonulin was significantly higher (p<0.05) in hypertensive subjects and positively associated (p<0.05) with systolic blood pressure (SBP) in females. A positive relationship (p<0.05) was observed between zonulin and measurements of obesity. Moreover, zonulin negatively associated (p<0.05) with ADMA but positively associated (p<0.05) with NO in males. Increased VF and waist circumference predicted gut permeability.ConclusionGut permeability was associated with hypertension and measures of obesity but not with markers of endothelial dysfunction in a South African youth population.© 2021 Ntlahla EE et al.

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