• Maha M Al-Bazi, Taha A Kumosani, Abdulrahman L Al-Malki, Kurunthachalam Kannan, and Said S Moselhy.
• Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), PO Box 80203, Jeddah, Saudi Arabia.
• Afr Health Sci. 2021 Sep 1; 21 (3): 1451-1459.

BackgroundThe metabolic pathways can be affected by dysregulation in thyroid hormone levels which in turn can arise from environmental chemical exposure. This study investigated the association of selected trace elements with thyroid disorders in a Saudi population.MethodsUrine samples collected from 100 participants (50 thyroid disorder patients and 50 controls) were analyzed to determine trace elements using inductively coupled plasma-mass spectrometer. Non-parametric Mann-Whitney Test, were used to examine the association between socio-demographic as well as clinical characteristics of thyroid profile levels (T3, T4 and TSH) and urinary trace element concentrations.ResultsUrine from patients with thyroid disorders had significantly higher concentrations of Ni, Cu, and Cd (p-values <0.0005). In contrast, urinary Cr and Zn (p-values <0.013 and 0.005) were low in thyroid patients compared to the control.ConclusionFirst study to report urinary trace element levels showed a possible link between thyroid disorders and trace element exposure which reflect the environmental pollution..© 2021 Al-Bazi MM et al.

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