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J Coll Physicians Surg Pak · Apr 2022
Does Albumin Level Change the Strength of the Memorial Sloan Kettering Cancer Center Nomogram Used to Predict 5-year Survival in Patients with Colon Cancer?
- Mehmet Kubat, Bahadir Osman Bozkirli, Mustafa Omer Yazicioglu, and Riza Haldun Gundogdu.
- Department of General Surgery, Alanya Training and Research Hospital, Alanya, Turkey.
- J Coll Physicians Surg Pak. 2022 Apr 1; 32 (4): 467-472.
ObjectiveTo test the efficacy of including albumin in the Memorial Sloan Kettering Cancer Center (MKSCC) nomogram (MSKCC+A) on predicting the overall survival.Study DesignDescriptive study.Place And Duration Of StudyAnkara Training and Research Hospital & Ataturk Training and Research Hospital, Turkey, in 2020, on patients who were operated between 2009 and 2014 to confirm the 5-year survival results.MethodologyPatients who underwent R0 resection for colon cancer were evaluated. For each patient in the cohort, the 5-year probability of survival was calculated and compared with actual, using the AJCC (American Joint Committee on Cancer), MSKCC and MSKCC+A estimation systems obtained using logistic regression. The performance of the estimation methods was evaluated by the ROC analysis.ResultsTwo hundred and thirty-nine patients were studied. When the patients with more than 5-year overall survival were compared, the AJCC, MSKCC, and enhanced MSKCC survival scores were significantly higher. AUC = 0.699 for the AJCC staging system, AUC = 0.702 for the MKSCC nomogram, and AUC = 0.777 when the albumin level was added to the MKSCC system.ConclusionsThe use of the MSKCC overall survival nomogram in patients with colon cancer appears useful for both clinicians and patients. The prognostic power of this calculator was found to be further enhanced by including the preoperative serum albumin level as an extra variable in the nomogram.Key WordsNomograms, Neoplasm grading, Survival, Colon cancer, Serum albumin.
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