• Charles Bitamazire Businge, Benjamin Longo-Mbenza, Oladele Vincent Adeniyi, Moise Mvitu Muaka, Georges Mvumbi Lelo, Mireille Solange Nganga Nkanga, Jean-Marie Kavembe, Baudoin Buassa-Bu-Tsumbu, Jean-Rene' M'buyamba Kabangu, and Ter GoonDanielDFaculty of Health Sciences, University of Fort Hare, East London, South Africa..
• Walter Sisulu University, Faculty of Health Sciences, Mthatha, South Africa.
• Afr Health Sci. 2018 Dec 1; 18 (4): 909-916.

BackgroundThis study determined the diagnostic performance of new biomarkers for a composite diagnosis of non-communicable diseases (NCDs) among Central Africans.MethodsThis case-control study was conducted at LOMO Medical Centre, Kinshasa, DR Congo (DRC) between January - December, 2008. The cases comprised 226 participants with concurrent presence of at least 2 or more of NCDs. Anthropometric parameters and blood pressure were measured while blood samples were assayed for biomarkers. The receiver operating characteristics curve and the logistic regression model were applied.ResultsSerum selenium (Se) had specificity and sensitivity of 72.4% and 91.1%, respectively with an area under the curve (AUC) of 0.802; Nitric oxide (NO) (specificity: 72.4%; sensitivity: 93.0%) (AUC = 0.800); Thyroid stimulating hormone (TSH) levels > 6 Mu/L (specificity: 75%; sensitivity: 65%) (AUC = 0.0.727); serum calcium levels of ≥ 110g/L (specificity: 76%; sensitivity: 75%) (AUC = 0.822); and daily salt intake of ≥10 g/day (specificity: 75%; sensitivity: 67%) (AUC = 0.653) in the diagnosis of all NCDs, which were all highly significant (<0.0001).ConclusionSerum Se, NO, calcium, TSH and daily salt intake had high diagnostic performance as biomarkers for identification of patients with concurrent NCDs in the study population.

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