• M B Adegboye, I K Kolawole, and B O Bolaji.
• Department of Anaesthesia, Faculty of Clinical Sciences, College of Health Sciences, University of Ilorin/ University of Ilorin Teaching Hospital, Ilorin, Nigeria.
• Afr Health Sci. 2018 Dec 1; 18 (4): 128312911283-1291.

IntroductionThe duration of action of sub-arachnoid block is short, and one of the ways to overcome this is the use of oral clonidine.Methods108 patients of ASA I and II, aged 18 to 65 years undergoing lower abdominal surgeries under spinal anaesthesia were randomized into three groups.. Control group A (n=36) no oral clonidine pre-medication, Group B (n=36) and group C (n=36) received 100 µg and 200 µg of oral clonidine pre-medication respectively, 1hr before spinal anaesthesia. Haemodynamic parameters were recorded. Sensory block, degree of motor blockage, and sedation were assessed.ResultsClonidine prolonged the mean duration of motor block by 189.98±26.93 min (100µg) and 191.89±28.13 min (200µg) compared to 117.92±25.13 min in the control group p<0.05. The mean duration of analgesia was 188.19±35 min (100µg) and194±24.58 min (200µg) in the clonidine groups compared to 115.89±26.66 min in control group p<0.05. All the patients were awake in the control group while 71.43% and 100% were drowsy in groups B and C respectively.ConclusionOral clonidine produces better clinical effects on the onset and duration of Bupivacaine spinal anaesthesia.

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