• Naomi C Brownstein, Harika Reddy, Junmin Whiting, Monica L Kasting, Katharine J Head, Susan T Vadaparampil, Anna R Giuliano, Clement K Gwede, Cathy D Meade, and Shannon M Christy.
• Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL, United States of America; Department of Oncologic Sciences, University of South Florida, United States of America. Electronic address: brownstn@musc.edu.
• Prev Med. 2022 Jul 1; 160: 107038107038.

BackgroundVaccination for SARS-CoV-2, the virus that causes COVID-19 illness, is an important public health tool to reduce hospitalizations and deaths.PurposeThis report focuses on intentions and behaviors related to COVID-19 vaccination among United States (U.S.) adults ages 18-45.MethodsFrom February 25-March 24, 2021, we conducted an online survey assessing COVID-19 vaccine intentions and behaviors, health beliefs, vaccine attitudes, and sociodemographic characteristics. Participants were adults aged 18-45, living throughout the U.S. with oversampling in Florida, panelists of a research panel company directly or via verified partners, and able to read, write, and understand English. Associations between COVID-19 vaccination uptake, intentions, and other study variables were examined through multivariable logistic and proportional odds regression analyses.ResultsAmong participants in the final analytic sample (n = 2722), 18% reported having received at least one dose of a COVID-19 vaccine. Approximately 31% of unvaccinated participants reported strong intentions to receive a COVID-19 vaccine in the next year, whereas 35% reported strong intentions to receive a COVID-19 vaccine if it were strongly recommended by a healthcare provider. All COVID-19 vaccination outcomes were associated with male gender, sexual minority status, higher levels of education, and previous influenza vaccination. All vaccination intention outcomes were associated with vaccine attitudes and geographic region. Vaccination status and intentions were differentially associated with multiple additional sociodemographic, attitudinal, and/or healthcare experience variables.ConclusionsSeveral demographic variables, vaccine attitudes, and healthcare experiences were found to contribute to COVID-19 vaccine receipt and intentions. Targeted efforts are necessary to increase uptake of the vaccine in the U.S.Copyright © 2022. Published by Elsevier Inc.

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