• African health sciences · Dec 2018

    Comparative Study

    comparative study of carbohydrate antigen 19-9 in sickle cell disease subjects and controls in Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.

    • Patrick Manafa, Chide Okocha, Benedict Nwogho, John Aneke, Paul Smith Davis Okpara, Nancy Lbeh, George Chukwuma, Vera Manafa, and Ejike Nwane.
    • Medical laboratory Science department, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State Nigeria.
    • Afr Health Sci. 2018 Dec 1; 18 (4): 1003-1009.

    BackgroundSickle cell disease is characterized by chronic complications that affect almost all body organs. Pancreatic disease is rare in SCD. CA 19-9 is a non-specific surrogate marker for pancreatic disease especially carcinoma. CA 19-9 levels have not been evaluated in SCD patients in our environment.ObjectivesThe study aimed to compare the levels of CA 19-9 in homozygous sickle cell disease subjects in steady state with those of (Hb AS) and normal healthy subjects (Hb AA).MethodSeventy nine subjects including 39 Hb SS, 19 Hb AS and 21 Hb AA subjects were recruited in a cross-sectional study in Nnamdi Azikiwe University and Teaching Hospital. Haemoglobin genotype and CA 19-9 estimation were done using Hb electrophoresis and enzyme linked immunosorbent assay respectively. Data was analyzed with IBM SPSS 21. P value was set at 0.05.ResultThe mean CA 19-9 (U/ml) level in Hb SS, Hb AS and Hb AA were 13.6 ± 7.6, 15.3 ± 9.9, and 20.0 ± 15.9 respectively. [Reference value <37U/ml] CA 19-9 was significantly lower in Hb SS compared to Hb AA subjects (p = 0.035).ConclusionLow levels of CA 19-9 in Hb SS may suggest reduced pancreatic disorders in SCA.

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