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African health sciences · Jun 2019
Polysaccharides obtained from mycelia of Cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy.
- Ruo-Kai Lin, Chen-Yen Choong, Wei-Hsuan Hsu, Chen-Jei Tai, and Cheng-Jeng Tai.
- Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, Taipei Medical University, Taipei, Taiwan.
- Afr Health Sci. 2019 Jun 1; 19 (2): 2156-2163.
ObjectivesFungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy.MethodsDoxorubicin was used to induce cytotoxicity in THP-1 monocytes and EL-4 T cells, and the effects of PS-MCM on cell viability and cytokine production were detected on doxorubicin-treated THP-1 and EL-4 cells.ResultsPS-MCM reduced doxorubicin-induced cell death and promoted cell proliferation in THP-1 and EL-4 cells. Moreover, PS-MCM elevated the level of cytokines associated with immune-modulation of THP-1 and EL-4 cells.ConclusionThese findings indicate that PS-MCM has potential for development as a functional food to counteract side effects of chemotherapy.© 2019 Lin et al.
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