• Nutrition · Oct 2010

    Effects of maternal undernutrition during lactation on estrogen and androgen receptor expressions in rat ovary at puberty.

    • Tatiane da Silva Faria, Flávia de Bittencourt Brasil, Francisco J B Sampaio, and Cristiane da Fonte Ramos.
    • Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
    • Nutrition. 2010 Oct 1; 26 (10): 993-9.

    ObjectiveThe aim of this study was to evaluate the effects of maternal protein and energy-restricted diets during lactation in folliculogenesis and its relations to androgen and estrogen receptors in the offspring at puberty.MethodsAt parturition, dams were randomly assigned to a control (C) group, with free access to a standard laboratory diet containing 23% protein; a protein-energy-restricted (PER) group, with free access to an iso-energy and protein-restricted diet containing 8% protein; and an energy-restricted (ER) group, receiving standard laboratory diet in restricted quantities. After weaning, female pups had free access to standard laboratory diet.ResultsThe number of preantral (C 13.72 ± 2.87, PER 26.36 ± 3.03, ER 26.88 ± 2.31, P < 0.05) and small antral (C 9.32 ± 1.32, PER 17.64 ± 2.33, ER 17.04 ± 2.22, P < 0.05) follicles was significantly increased by maternal malnutrition. The number of primordial follicles (C 10.57 ± 1.61, PER 4.30 ± 0.62, ER 6.28 ± 1.30, P < 0.05), Graafian follicles (C 1.04 ± 0.09, PER 0.52 ± 0.10, ER 0.36 ± 0.11, P < 0.01), and corpus luteum (C 4.84 ± 0.62, PER 2.80 ± 0.50, ER 3.24 ± 0.27, P < 0.05) was significantly reduced. Maternal protein- and energy-restricted diets led to a significant decrease in the androgen (C 9815 ± 1015, PER 6071 ± 838.7, ER 5811 ± 699.3, P < 0.05) and estrogen (C 0.79 ± 0.244, PER 0.12 ± 0.035, ER 0.20 ± 0.036, P < 0.05) α-receptors. In growing follicles, androgen receptor was immuno-expressed in granulosa and theca cells. Estrogen receptor-α was mainly expressed in stroma cells.ConclusionOur results suggest that maternal protein- and energy-restricted diets during lactation can disturb the follicular development of the offspring, probably by reducing the number of androgen and estrogen receptors in the ovary.Copyright © 2010 Elsevier Inc. All rights reserved.

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