• Amjad M Yousuf, Firoz A Kannu, Talha M Youssouf, Fatimah N Alsuhaimi, Abdulaziz M Aljohani, Fayez H Alsehli, Omar F Khabour, Yahya A Almutawif, Mustafa A Najim, and Hatem A Mahmood.
• From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
• Saudi Med J. 2022 Feb 1; 43 (2): 132-138.

ObjectivesTo study the genotype and allele frequency of the fat mass and obesity-associated (FTO) rs8050136 A>C genetic variant and investigate its association with type 2 diabetes mekkitus (T2DM) parameters.MethodsThis study was carried out on 118 diabetic patients and 106 healthy individuals (control) from Prince Mohammed bin Abdulaziz Hospital, Al Madinah Al Munawarah, Saudi Arabia. The TaqMan single-nucleotide polymorphism (SNP)genotyping assay was used for rs8050136 genotyping.ResultsThe frequency of the genotype AA was the same among T2DM and healthy control groups (21%). However, the frequency of genotype CC was 19.5% in T2DM patients and 24.5% in control individuals. There was no significant association between FTO SNP rs8050136 and an increased risk of T2DM. Furthermore, there was no association between the risk AA genotype and fasting blood glucose (p=0.092), glycated hemoglobin (p=0.177), or body mass index (p=0.561).ConclusionOur findings show that the FTO rs8050136 A>C variant is not associated with T2DM in the Saudi population.Copyright: © Saudi Medical Journal.

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