• Mohammed AlSheef, Ghaydaa Kullab, Modhi Alajmi, Ruba Aldhaheri, Sultan Al Baqmi, Haya Alajlan, Abdul Rehman Z Zaidi, and Amani Abu-Shaheen.
• From the Medical Specialties Department (AlSheef), from the Internal Medicine Department (Kullab), from the Research Center (Abu-Shaheen), King Fahad Medical City; from the Internal Medicine Department (Kullab, Zaidi), Dr. Sulaiman Al Habib Medical Group, Riyadh; from the College of Medicine (Al Baqmi), King Saud Bin Abdulaziz University for Health Sciences; from the College of Health and Rehabilitation Sciences (Alajlan), Princess Noura Bint Mohammed University, Riyadh; from the College of Medicine (Alajmi), Imam Abdulrahman Bin Faisal University, Dammam; and from the College of Medicine (Aldhaheri), King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
• Saudi Med J. 2022 Feb 1; 43 (2): 213-217.

ObjectivesTo share clinical data on the efficacy of 4F-PCC in the treatment of major bleeding caused by warfarin, dabigatran, and rivaroxaban.MethodsThis is a retrospective study of patients admitted to King Fahad Medical City, Riyadh, Saudi Arabia with major bleeding caused by oral anticoagulants and treated with 4-factor prothrombin complex concentrate (4F-PCC). The International Society of Thrombosis and Hemostasis Scientific and Standardization Subcommittee criteria were used to evaluate the effectiveness of PCCs.ResultsA total of 22 patients were included in the study. Ten of the events were caused by gastrointestinal bleeding (46%). In the majority of patients, anticoagulation was prescribed for stroke prevention, atrial fibrillation, and venous thromboembolism. The median international normalized ratio was significantly lower before and after PCC administration (p<0.001). In patients treated with 4-factor PCC, the rate of thromboembolic events was 0%. The hemostatic effectiveness of PCC was effective in 19 patients. During treatment, no clinically significant bleeding complications occurred.ConclusionProthrombin complex concentrate can effectively reverse the effects of warfarin and rivaroxaban in patients with major bleeding, but only partially reverses the effect of dabigatran.Copyright: © Saudi Medical Journal.

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