• João Araújo Barros-Neto, Carolina Santos Mello, Sandra Mary Lima Vasconcelos, Gabriel Soares Bádue, Raphaela Costa Ferreira, Maria Izabel Siqueira de Andrade, Carlos Queiroz do Nascimento, MacenaMateus de LimaMLFaculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil., José Adailton da Silva, Heleni Aires Clemente, Marina de Moraes Vasconcelos Petribu, Keila Fernandes Dourado, Claudia Porto Sabino Pinho, VieiraRenata Adrielle LimaRALEscola de Nutrição, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., Leilah Barbosa de Mello, Mariana Brandão das Neves, Camila Anjos de Jesus, Tatiana Maria Palmeira Dos Santos, Bruna Lúcia de Mendonça Soares, Larissa de Brito Medeiros, Amanda Pereira de França, Ana Lina de Carvalho Cunha Sales, Elane Viana Hortegal Furtado, Alane Cabral Oliveira, Fernanda Orrico Farias, Mariana Carvalho Freitas, and Nassib Bezerra Bueno.
• Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, Brazil. Electronic address: joao.neto@fanut.ufal.br.
• Nutrition. 2022 Sep 1; 101: 111677111677.

ObjectivesThe present study aimed to identify associations between extremes in body weight status (underweight and excess body weight) before a COVID-19 diagnosis and clinical outcomes in patients infected with SARS coronavirus type 2.MethodsA multicenter cohort study was conducted in eight different states in northeastern Brazil. Demographic, clinical (previous diagnosis of comorbidities), and anthropometric (self-reported weight and height) data about individuals who tested positive for COVID-19 were collected. Outcomes included hospitalization, mechanical ventilation, and death. Multivariable logistic regression models, adjusted based on age, sex and previous comorbidities, were used to assess the effects of extremes in body weight status on clinical outcomes.ResultsA total of 1308 individuals were assessed (33.6% were elderly individuals). The univariable analyses showed that only hospitalization was more often observed among underweight (3.2% versus 1.2%) and overweight (68.1% versus 63.3%) individuals. In turn, cardiovascular diseases were more often observed in all clinical outcomes (hospitalization: 19.7% versus 4.8%; mechanical ventilation: 19.9% versus 13.5%; death: 21.8% versus 14.1%). Based on the multivariable analysis, body weight status was not associated with risk of hospitalization (underweight: odds ratio [OR]: 1.10; 95% confidence interval [CI] 95%, 0.50-2.41 and excess body weight: OR: 0.81; 95 CI, 0.57-1.14), mechanical ventilation (underweight: OR: 0.92; 95% CI, 0.52-1.62 and excess weight: OR: 0.90; 95% CI, 0.67-1.19), and death (underweight: OR: 0.61; 95% CI, 0.31-1.20 and excess body weight: OR 0.88; 95% CI, 0.63-1.23).ConclusionsBeing underweight and excess body weight were not independently associated with clinical outcomes in patients with COVID-19 in the herein analyzed cohort. This finding indicates that the association between these variables may be confounded by both age and comorbidities.Copyright © 2022 Elsevier Inc. All rights reserved.

20 keywords...

hide…