• Gabriela Ferreira Abud, Flavia Giolo De Carvalho, Gabriela Batitucci, Sofia Germano Travieso, Carlos Roberto Bueno Junior, Barbosa JuniorFernandoFDepartment of Clinical, Toxicologic and Bromatological Analysis, College of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo - FCFRP USP, Ribeirao Preto, Sao Paulo, Brazil., Julio Sergio Marchini, and Ellen Cristini de Freitas.
• Department of Food and Nutrition, School of Pharmaceutical Sciences of Araraquara, State University of Sao Paulo - FCF UNESP, Araraquara, Sao Paulo, Brazil.
• Nutrition. 2022 Sep 1; 101: 111706.

ObjectiveBased on the antioxidant effects of taurine, which are capable of controlling oxidative stress in the aging process, the aim of this study was to investigate the effects of taurine supplementation on biomarkers of oxidative stress in women 55 to 70 y of age.MethodsA double-blind study was conducted with 24 women (61.4 ± 4.2 y, body mass index 31.4 ± 5.1 kg/m²). The participants were randomly assigned to either a control group (GC, n = 11), supplemented with placebo (1.5 g of starch); or a taurine group (GTAU, n = 13), supplemented with taurine (1.5 g), for 16 wk. As primary outcomes, taurine and oxidative stress marker levels were determined in plasma samples. Anthropometry, functional capacity testing, and plasma mineral levels were evaluated as secondary outcomes. The evaluations were performed pre- and postintervention. Food consumption was assessed before, during, and after the intervention. The results were analyzed by two-way repeated analysis of variance measures mixed model, with the Sidak post hoc (P < 0.05).ResultsTaurine and superoxide dismutase (SOD, antioxidant enzyme) plasma levels were increased in the GTAU group. SOD levels also were higher than in the GC group after supplementation. Glutathione reductase levels decreased regardless of the intervention. Malondialdehyde levels increased only in the GC participants.ConclusionTaurine supplementation prevented the decrease in the antioxidant enzyme SOD, suggesting taurine as a strategy to control oxidative stress during the aging process.Copyright © 2022 Elsevier Inc. All rights reserved.

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