• Valentin Bossard, Nicolas Bourmeyster, Sophie Pasini, Pierre Dupuis, Souleiman El Balkhi, Emmanuel Richard, Hugo Alarcan, Thierry Hauet, and Raphael Thuillier.
• CHU de Poitiers, Service de Biochimie, Poitiers, France; Université de Poitiers, Faculté de Médecine et Pharmacie, Poitiers, France.
• Nutrition. 2022 Oct 1; 102: 111738.

ObjectivesDue to the increased prevalence of obesity in the world, bariatric surgeries are on the rise and necessitate life-long surveillance for deficiencies; hence the recommended vitamin supplementation in these patients. However, inadequate multivitamin supplementation may induce vitamin B6 overload.MethodsWe reviewed all vitamin B6 dosages at the university hospitals of Poitiers, Tours, Bordeaux, and Limoges for the past 5 to 8 years. Analyses were performed by high-performance liquid chromatography, coupled with a fluorescence detector on whole blood samples.ResultsDuring the study period, there was an increase in the number of vitamin B6 dosages. Deficiencies were detected early in Poitiers and Limoges, but were negligible by 2020. However, during the same time period, the number of overdoses increased, reaching close to 40% of dosages at all centers.ConclusionsPyridoxin overload is not possible through food-derived pyridoxin; hence, combined with the fact that most vitamin supplements contain vitamin B6, inadequate vitamin supplementation is likely the cause of the observed increase in overdoses. High doses of vitamin B6 can induce polyneuropathy, particularly targeting motor neurons; thus, the increase of overdoses is worrying. In light of the possible risks and the ease with which these could be averted (better formulation of supplements), the precaution principle requires a definition of clear guidelines for vitamin supplementation, especially in patients undergoing bariatric surgery.Copyright © 2022 Elsevier Inc. All rights reserved.

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