• Selim Afsar, Ayse Yigit, Ruhsen Ozcaglayan, Ceyda S Usta, Cagla B Bulbul, and Gulay Turan.
• From the Department of Obstetrics and Gynecology (Afsar, Usta, Bulbul); from the Department of Internal Medicine (Ozcaglayan); from the Department of Pathology (Turan), School of Medicine, Balikesir University, Balikesir, and from the Department of Obstetrics and Gynecology (Yigit), Adana Yuregir Devlet Hastanesi, Adana, Turkey.
• Saudi Med J. 2022 Jul 1; 43 (7): 694699694-699.

ObjectivesTo elucidate the link between fetuin-A expression in human umbilical vein endothelial cells (HUVECs) and amnion cells (ACs) and clinicopathological changes in patients with gestational diabetes mellitus (GDM) and newborns.MethodsThis retrospective cohort study included 82 pregnant patients (40 with GDM and 42 controls) between January 2019 and January 2022. The patients underwent a one-hour, 50 gram glucose challenge test (GCT) during the 24-28th weeks of pregnancy. Patients with positive GCTs immediately underwent a 3-hour, 100 gram oral glucose tolerance test. The expression level of fetuin-A in UVECs and ACs was evaluated by immunohistochemistry (IHC) and scored based on IHC staining in randomly selected slides. The IHC staining intensity was evaluated by the number of dots, which reflects the expression level of fetuin-A in both HUVECs and ACs.ResultsThe GDM group displayed significantly higher fetuin-A expression in both HUVECs (p<0.0001) and ACs (p=0.0001) when compared with the control group. Fetuin-A expression in HUVECs was correlated with fetal macrosomia, neonatal hypoglycemia, and placental weight. However, there was no correlation with fetuin-A expression in ACs.ConclusionThere is a correlation between fetal macrosomia, neonatal hypoglycemia, placental weight, and fetuin-A expression of HUVECs in patients with GDM.Copyright: © Saudi Medical Journal.

20 keywords...

hide…