• Neuroscience · May 2023

    Review

    Neuronal nuclear tau and neurodegeneration.

    • Alejandro Antón-Fernández, Laura Vallés-Saiz, Jesús Avila, and Félix Hernández.
    • Centro de Biología Molecular "Severo Ochoa", CSIC/UAM, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
    • Neuroscience. 2023 May 10; 518: 178184178-184.

    AbstractTau is a well-known microtubule-associated protein related to its cytoplasmic localization in a neuronal cell. However, tau has been located at the cell nucleus where it could be a nucleic acid-associated protein by its preferential binding to DNA sequences present in the nucleolus and pericentromeric heterochromatin. This less well-known localization of tau could not be trivial, since during aging, an increase in the amount of nuclear tau takes place and it may be related to the described role of tau in the activation of transposons and further aging acceleration.Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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