• Neuroscience · Jan 2023

    Review

    Looking for Guidance - Models and Methods to Study Axonal Navigation.

    • Alexandre Dumoulin and Esther T Stoeckli.
    • Department of Molecular Life Sciences and Neuroscience Center Zurich, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
    • Neuroscience. 2023 Jan 1; 508: 303930-39.

    AbstractThe molecular mechanisms of neural circuit formation have been of interest to Santiago Ramón y Cajal and thousands of neuroscientists sharing his passion for neural circuits ever since. Cajal was a brilliant observer and taught us about the connections and the morphology of neurons in the adult and developing nervous system. Clearly, we will not learn about molecular mechanisms by just looking at brain sections or cells in culture. Technically, we had to come a long way to today's possibilities that allow us to perturb target gene expression and watch the consequences of our manipulations on navigating axons in situ. In this review, we summarize landmark steps towards modern live-imaging approaches used to study the molecular basis of axon guidance.Copyright © 2022 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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