• Mehmet Hocaoğlu, Mark Denis P Davis, Shirley-Ann Osei-Onomah, Maria O Valenzuela-Almada, Jesse Y Dabit, Stephanie Q Duong, Jeffrey X Yang, Charles G Helmick, Cynthia Crowson, and Alí Duarte-García.
• Division of Rheumatology, Mayo Clinic, Rochester, MN; Department of Medicine, University of Maryland Medical Center, Midtown Campus, Baltimore.
• Mayo Clin. Proc. 2022 Dec 1; 97 (12): 228222902282-2290.

ObjectiveTo characterize the epidemiological trends and mortality of cutaneous lupus erythematosus (CLE) between 1976 and 2018 in Olmsted County, Minnesota.Patients And MethodsIn this retrospective population-based cohort study, all incident and prevalent CLE cases among adult residents in Olmsted County, Minnesota, between January 1, 1976, and December 31, 2018, were identified and categorized by subtype through medical record review using the resources of the Rochester Epidemiology Project.ResultsThe overall incidence rate of CLE between 1976 and 2018 was 3.9 (95% CI, 3.4 to 4.5) per 100,000. The incidence of CLE was relatively stable, with no major trend across sexes or age groups. The age- and sex-adjusted prevalence of CLE was 108.9 per 100,000 on January 1, 2015. Mortality in CLE patients was similar to that of the general population, with a standardized mortality ratio of 1.23 (95% CI, 0.88 to 1.66) with no observed trends in mortality over time.ConclusionIn the past 4 decades, the incidence of CLE remained stable. Patients with CLE have mortality comparable to that of the general population.Copyright © 2022 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

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