Year 3 of COVID-19: Harsh Truths, Brutal Realities, and Glimmers

Mayo Clinic proceedings · Dec 2022

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Year 3 of COVID-19: Harsh Truths, Brutal Realities, and Glimmers of Hope.

Severe acute respiratory syndrome coronavirus 2, the virus causing coronavirus disease 2019 (COVID-19), has now killed 1 of every 303 Americans. Whereas 4 vaccines are approved in the United States and masks are widely available, too few are fully immunized and most of the population has stopped wearing protective masks. The ongoing consequences of this include continued excess morbidity and mortality and the generation of immune-evading variants and subvariants, which in toto are injurious and ultimately self-defeating. Herein we briefly update and review COVID-19 vaccines, waning immunity, and new variants.

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- Gregory A Poland, Meltiady Issa, and Karna Sundsted.
- Mayo Clinic Vaccine Research Group, Department of Medicine, Mayo Clinic, Rochester, MN; Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN. Electronic address: poland.gregory@mayo.edu.
- Mayo Clin. Proc. 2022 Dec 1; 97 (12): 232423322324-2332.
AbstractSevere acute respiratory syndrome coronavirus 2, the virus causing coronavirus disease 2019 (COVID-19), has now killed 1 of every 303 Americans. Whereas 4 vaccines are approved in the United States and masks are widely available, too few are fully immunized and most of the population has stopped wearing protective masks. The ongoing consequences of this include continued excess morbidity and mortality and the generation of immune-evading variants and subvariants, which in toto are injurious and ultimately self-defeating. Herein we briefly update and review COVID-19 vaccines, waning immunity, and new variants.Copyright © 2022 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

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Year 3 of COVID-19: Harsh Truths, Brutal Realities, and Glimmers of Hope.

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