• Hollis T Cline, Melissa Lau, and Masaki Hiramoto.
• Department of Neuroscience and the Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA. Electronic address: cline@scripps.edu.
• Neuroscience. 2023 Jan 1; 508: 3183-18.

AbstractSensory information in the brain is organized into spatial representations, including retinotopic, somatotopic, and tonotopic maps, as well as ocular dominance columns. The spatial representation of sensory inputs is thought to be a fundamental organizational principle that is important for information processing. Topographic maps are plastic throughout an animal's life, reflecting changes in development and aging of brain circuitry, changes in the periphery and sensory input, and changes in circuitry, for instance in response to experience and learning. Here, we review mechanisms underlying the role of activity in the development, stability and plasticity of topographic maps, focusing on recent work suggesting that the spatial information in the visual field, and the resulting spatiotemporal patterns of activity, provide instructive cues that organize visual projections.Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.

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