• J Coll Physicians Surg Pak · Dec 2022

    Case Reports

    Ethylenediaminetetraacetic Acid-induced Pseudothrombocytopenia in Association with Graves' Hyperthyroidism.

    • Jing Jing, Jingwen Li, and Minmin Yu.
    • Department of Endocrinology, Qingdao Municipal Hospital, Qingdao, Shandong, China.
    • J Coll Physicians Surg Pak. 2022 Dec 1; 32 (12): SS146SS148SS146-SS148.

    AbstractEthylenediaminetetraacetic acid-dependent pseudothrombocytopenia (EDTA-PTCP) is an in vitro phenomenon of EDTA-induced platelet aggregation. A number of mechanisms have been proposed to account for this phenomenon. EDTA-PTCP has been found in healthy subjects and patients with a variety of conditions, including viral infections, cardiovascular disease, liver disease, neoplastic diseases and autoimmune diseases. In the present case, a 66-year male had a 5-month history of palpitations. The patient presented with Graves' hyperthyroidism and was diagnosed with transient EDTA-PTCP. With the improvement of hyperthyroidism, the phenomenon of EDTA-PTCP disappeared. So far, EDTA-PTCP related to Graves' hyperthyroidism has not been reported in the literature. Key Words: Hyperthyroidism, Thrombocytopenia, Autoimmune diseases, Platelet aggregation, Edetic acid.

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