• Defu Li, Hongbing Li, Yujin Wang, and Tingting Zhu.
• Department of Radiology, Fuyong People’s Hospital of Shenzhen Bao’an, Shenzhen, China
• Pol. Arch. Med. Wewn. 2023 Feb 27; 133 (2).

IntroductionInterstitial lung disease (ILD) is common in patients with primary Sjögren syndrome (pSS). Pulmonary fibrosis significantly reduces the patient's quality of life. Therefore, better understanding of the characteristics of patients with pulmonary fibrosis is necessary.ObjectivesThe aim of the study was to evaluate the computed tomography (CT) and clinical features of pSS‑related ILD and to explore the factors associated with fibrotic ILD in patients with pSS.Patients And MethodsIn total, 151 patients with pSS‑related ILD were retrospectively studied for their demographic and clinical characteristics. The patients were categorized into the nonfibrosing ILD and fibrosing ILD groups based on their CT findings. The clinicl, laboratory, and CT findings from both groups were compared to determine the influencing factors associated with the condition.ResultsThe nonfibrosing ILD and fibrosing ILD groups comprised 103 and 48 patients, respectively. As compared with the nonfibrosing ILD group, the fibrosing ILD group had a shorter disease duration, higher frequency of dry cough and shortness of breath, more patients with ground‑glass opacity, mediastinal lymph node disease, and pleural lesions on chest CT, and lower frequency of dry mouth and eyes. Dry cough and shortness of breath were independent predictors of pulmonary fibrosis in the patients with pSS (P = 0.01 and P = 0.02, respectively).ConclusionsThe presence of dry cough and shortness of breath in the patients with pSS may indicate concomitant pulmonary fibrosis. High‑resolution chest CT can be used for better insights on the occurrence and severity of pulmonary fibrosis in these patients.

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