• Maísa Miranda Araújo, Marcela Moraes Mendes, Lorena Morais Costa, Ricardo Moreno Lima, Susan A Lanham-New, Baiocchi de CarvalhoKênia MaraKMGraduate Program in Human Nutrition, University of Brasília, Brasília, Brazil., and Patrícia Borges Botelho.
• Graduate Program in Human Nutrition, University of Brasília, Brasília, Brazil.
• Nutrition. 2023 Apr 1; 108: 111937111937.

ObjectivesThe aim of this study was to evaluate bone health and the potential influencing factors of bone metabolism disorders in adults ≥5 y after Roux-en-Y gastric bypass (RYGB) surgery.MethodsIn this cross-sectional study, patients who were ≥5 y post-RYGB were invited. Bone health considered as bone mineral content (BMC) and bone mineral density (BMD) in this study was assessed by dual x-ray absorptiometry. We also assessed 25-hydroxy-vitamin D concentrations, individual ultraviolet B radiation levels, serum ionized calcium, alkaline phosphatase, parathyroid, anthropometric, and body composition.ResultsThe study evaluated 104 adults (90% women; 49.6 ± 9.1 y old; postoperative period 8.7 ± 2.2 y). Lumbar and femoral BMC and BMD were positively correlated to body mass index (BMI), appendicular lean mass (ALM), and negatively to %excess of weight loss (EWL). Femoral BMD was negatively correlated to age, and both femoral BMD and BMC were positively correlated to weekly exposed body part score. Sex, age, BMI, ALM, and weekly exposed body part score explained 35% and 54% of the total variance of femoral BMD and BMC, respectively.ConclusionsThe present findings suggested that older age, lower BMI, higher %EWL, lower ALM, and lower weekly body part exposure score are important determinants in lowering BMD and BMC parameters in long-term post-bariatric surgery individuals, rather than serum 25-hydroxy-vitamin D and parathyroid.Copyright © 2022 Elsevier Inc. All rights reserved.

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