• Nutrition · Apr 2023

    Protective effects of Yerba mate (IIex paraguariensis) on prostate cancer development.

    • Flavia E Santiano, María de Los Ángeles Fernández, Magdalena Espino, Leila E Zyla, Lara Rey, Silvina E Gómez, Flavia A Bruna, Virginia Pistone-Creydt, Elisa Pietrobon, Rafael Pérez Elizalde, María F Silva, Rubén W Carón, and Constanza M López Fontana.
    • Laboratory of Hormones and Cancer Biology, Institute of Medicine and Experimental Biology of Cuyo (IMBECU), National University of Cuyo (UNCuyo), National Council for Scientific and Technical Research (CONICET), Mendoza, Argentina. Electronic address: fsantiano@mendoza-conicet.gob.ar.
    • Nutrition. 2023 Apr 1; 108: 111957111957.

    ObjectivesProstate cancer (PCa) is the most common adenocarcinoma in men >50 y of age. It has a long latency period, which provides time for preventive strategies like incorporating healthy eating habits. Yerba mate (YM) intake has been associated with numerous health benefits. Since YM is one of the most popular infusions in Argentina, the of this study was to examine the influence of YM on PCa development.MethodsWe carried out an in vivo model of PCa through subcutaneous inoculation of transgenic adenocarcinoma of the mouse prostate-C1 cells in C57BL/6 mice. Subsequently, the animals were divided into two groups: mate (25 mg/mL of YM in drinking water, n = 15), and control (only drinking water, n = 15). We also developed an in vitro model to study the direct effects of YM on three human PCa cell lines: lymph node carcinoma of the prostate (LNCaP), PC-3, and DU-145.ResultsOur in vivo model showed that YM intake slightly reduced body weight, increased the latency of tumor appearance (P <0.01), and diminished the tumor volume (P <0.05) compared with the control group. In agreement, the expression of proliferating cell nuclear antigen, and nuclear estrogen receptor α were lower in the tumors of the mate animals (P <0.05). In vitro, YM decreased the viability, proliferation, and adhesion of the three tumor cell lines (P < 0.001) and retarded the migration of LNCaP (P <0.05) and DU-145 (P <0.005), without modifying the migration of PC-3 cells.ConclusionsYM showed anticancer effects in vitro and in vivo and were more effective on the androgen-sensitive cell line (LNCaP).Copyright © 2022 Elsevier Inc. All rights reserved.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…