• Neuroscience · May 2023

    Review

    Neuroprotective effects of N-acetylserotonin and its derivative.

    • Ji-He Kang, Xu-Dong Guo, Yi-Dian Wang, and Xue-Wen Kang.
    • Orthopedics Department, the Second Hospital of Lanzhou University, Lanzhou, China; Orthopedics Department, the Second Clinical Medical College of Lanzhou University, Lanzhou, China.
    • Neuroscience. 2023 May 1; 517: 182518-25.

    AbstractN-acetylserotonin (NAS) is a chemical intermediate in melatonin biosynthesis. NAS and its derivative N-(2-(5-hydroxy-1H-indol-3-yl) ethyl)-2-oxopiperidine-3-carboxamide (HIOC) are potential therapeutic agents for traumatic brain injury, autoimmune encephalomyelitis, hypoxic-ischemic encephalopathy, and other diseases. Evidence shows that NAS and its derivative HIOC have neuroprotective properties, and can exert neuroprotective effects by inhibiting oxidative stress, anti-apoptosis, regulating autophagy dysfunction, and anti-inflammatory. In this review, we discussed the neuroprotective effects and related mechanisms of NAS and its derivative HIOC to provide a reference for follow-up research and applications.Copyright © 2023 IBRO. Published by Elsevier Ltd. All rights reserved.

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