• Fatemeh Tabassi Mofrad and Niels O Schiller.
• Leiden University Centre for Linguistics, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands; Institute of Cognitive Neuroscience, University College London, London, UK. Electronic address: f.tabassi.mofrad@fsw.leidenuniv.nl.
• Neuroscience. 2023 May 21; 519: 191-9.

AbstractAccording to the correlated transmitter-receptor based structure of the inferior parietal cortex (IPC), this brain area is divided into three clusters, namely, the caudal, the middle and the rostral. Nevertheless, in associating different cognitive functions to the IPC, previous studies considered this part of the cortex as a whole and thus inconsistent results have been reported. Using multiband echo planar imaging (EPI), we investigated the connectivity profile of the middle IPC while forty-five participants performed a task requiring cognitive control. The middle IPC demonstrated functional associations which do not have similarities to a contributing part in the frontoparietal network, in processing cognitive control. At the same time, this cortical area showed negative functional connectivity with both the precuneus cortex, which is resting- state related, and brain areas related to general cognitive functions. That is, the functions of the middle IPC are not accommodated by the traditional categorization of different brain areas i.e. resting state-related or task-related networks and this advanced our hypothesis about modulating cortical areas. Such brain areas are characterized by their negative functional connectivity with parts of the cortex involved in task performance, proportional to the difficulty of the task; yet, their functional associations are inconsistent with the resting state-related cortical areas.Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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