Exposure to trans fat during the developmental period

Neuroscience · May 2023

Exposure to trans fat during the developmental period ofDrosophila melanogasteralters the composition of fatty acids in the head and induces depression-like behavior.

Given the importance of understanding the disorders caused by trans fatty acids (TFAs), this study sought to add different concentrations hydrogenated vegetable fat (HVF) to the diet of Drosophila melanogaster during the developmental period and evaluate the effects on neurobehavioral parameters. Longevity, hatching rate, and behavioral functions were assessed, such as negative geotaxis, forced swimming, light/dark, mating, and aggressiveness. ⋯ As for the biochemical parameters, there was a more significant presence of TFA in flies exposed to HVF at all concentrations evaluated and lower 5HT and DA levels. This study shows that HVF during the developmental phase can cause neurological changes and consequently induce behavioral disorders, thereby highlighting the importance of the type of FA offered in the early stages of life.

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- Luana Barreto Meichtry, da SilvaGuilherme SilvaGSLaboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa - Campus Itaqui - Rua Luiz Joaquim de Sá Britto, Promorar, Itaqui, Rio Grande do Sul CEP 9, Larissa Londero, Mustafa DahlehMustafa MunirMMLaboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa - Campus Itaqui - Rua Luiz Joaquim de Sá Britto, Promorar, Itaqui, Rio Grande do Sul C, Vandreza Cardoso Bortolotto, Stífani Machado Araujo, Elize Aparecida Musachio, da SilvaDariane TrivisiolDTDepartamento de Tecnologia e Ciência dos Alimentos, Centro de Ciências Rurais Universidade Federal de Santa Maria, Santa Maria, RS CEP 97105-900, Brazil., Tatiana Emanuelli, Sigal CarriçoMurilo RicardoMRUniversidade Federal do Pampa - Campus Uruguaiana, Programa de Pós-Graduação em Bioquímica (PPGBioq), BR-472 Km 7, Uruguaiana CEP 97501-970, Brazil., Rafael Roehrs, Gustavo Petri Guerra, and Marina Prigol.
- Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas - LaftamBio Pampa - Universidade Federal do Pampa - Campus Itaqui - Rua Luiz Joaquim de Sá Britto, Promorar, Itaqui, Rio Grande do Sul CEP 97650-000, Brazil.
- Neuroscience. 2023 May 21; 519: 102210-22.
AbstractGiven the importance of understanding the disorders caused by trans fatty acids (TFAs), this study sought to add different concentrations hydrogenated vegetable fat (HVF) to the diet of Drosophila melanogaster during the developmental period and evaluate the effects on neurobehavioral parameters. Longevity, hatching rate, and behavioral functions were assessed, such as negative geotaxis, forced swimming, light/dark, mating, and aggressiveness. The fatty acids (FAs) present in the heads of the flies were quantified as well as serotonin (5HT) and dopamine (DA) levels. Our findings showed that flies that received HVF at all concentrations during development showed reduced longevity and hatching rates, in addition to increased depression-like, anxious-like, anhedonia-like, and aggressive behaviors. As for the biochemical parameters, there was a more significant presence of TFA in flies exposed to HVF at all concentrations evaluated and lower 5HT and DA levels. This study shows that HVF during the developmental phase can cause neurological changes and consequently induce behavioral disorders, thereby highlighting the importance of the type of FA offered in the early stages of life.Copyright © 2023 IBRO. Published by Elsevier Ltd. All rights reserved.

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Exposure to trans fat during the developmental period ofDrosophila melanogasteralters the composition of fatty acids in the head and induces depression-like behavior.

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