• African health sciences · Dec 2022

    In-vitro antioxidant potential and acetylcholinesterase inhibitory effect of Ficus benghalensis aerial root extract.

    • Anand Ramasamy, K Anandakumar, and K Kathiresan.
    • Research Scholar, Department of Pharmacy, Annamalai University, Annamali Nagar, Tamil Nadu, India.
    • Afr Health Sci. 2022 Dec 1; 22 (4): 291299291-299.

    Aim And ObjectiveThe aim of the current study was to evaluate the antioxidant effect, acetylcholinesterase (AChE) inhibitory effect and phytochemical screening of different extracts of aerial root extract of Ficus benghalensis using in-vitro methods.MethodsThe aerial root extract was prepared by successive extraction method using different organic solvents having increasing order of polarity. FB aerial root extract was screened for preliminary phytochemical analysis. FB aerial root extracts were evaluated for in-vitro acetylcholinesterase inhibitory effect by the Ellman's method and anti-oxidant potential by DPPH assay and hydroxyl radical neutralizing assay.ResultsPreliminary phytochemical screening of FB extracts indicate the existence of the phytochemicals such as phenols, alkaloids, flavonoids, glycosides, anthraquinones, tannins and steroids. The results of the DPPH assay, hydroxyl radical scavenging assay and AChE inhibitory assay show that chloroform and ethyl acetate extracts are having significant antioxidant activity and acetylcholinesterase inhibitory effect as compared to the other extracts, respectively.ConclusionThe results of the current study suggest that the aerial root extract of FB might be a potential drug source for treatment of neurodegenerative disorders like Alzheimer disease.© 2022 Ramasamy A et al.

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