• Badru Ssekitooleko, Bashir Ssuna, Stella Alice Nimanya, Ronald Kiwewa, Yasin Ssewanyana, Emmanuel Nkonge, Emmanuel Bua, Joel Wandabwa, William Ocen, Rosemary Nassanga, Frank Asiimwe, and Robert Kalyesubula.
• Makerere University College of Health Sciences, School of Medicine.
• Afr Health Sci. 2022 Dec 1; 22 (4): 191198191-198.

IntroductionAcute kidney injury (AKI) is a common and life-threatening complication of major trauma. Recognition is often delayed and management is frequently sub-optimal. We determined the incidence, risk factors and immediate outcomes of AKI in patients with major trauma at Mulago National Referral Hospital.MethodsThis was a prospective study. We recruited adult patients with ISS of > 16. The KDIGO criteria was used to stage AKI. Serum creatinine was measured at baseline, 24, 48, 72 hours and on discharge from the study. Participants were followed up for seven days if not yet discharged. Bivariate and multivariate analysis was done using modified Poisson regression with robust standard errors.Results224 patients were recruited. The incidence was 67/1000 persons per day. The risk factors were male sex, delayed presentation, hypoglycemia at admission, RR=1.62 (95%CI 1.24-2.12) and non-operative management RR=1.39 (95%CI 1.02-1.89). Out of the 62 patients that died, 34 (54.8%) had AKI. The overall mortality rate was 39.5 patients per thousand per day.ConclusionThere was a high incidence of AKI among patients with major trauma. Efforts to reduce morbidity and mortality should be prioritized.© 2022 Ssekitooleko B et al.

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