• Altaf Bandy, Farooq A Wani, Abdul H Mohammed, Umar F Dar, Ayesha Mallick, Mushtaq R Dar, and Bilal A Tantry.
• College of medicine, Jouf University, Sakaka, post code 42421, Saudi Arabia.
• Afr Health Sci. 2022 Dec 1; 22 (4): 576586576-586.

BackgroundManaging wound infections is a challenging task. Understanding their resistance pattern is an essential step at reducing its burden in hospital settings.ObjectiveTo determine the bacteriological diversity of wound infections and the antimicrobial resistance exhibited by a selected Gram-negative bacterium in the Aljouf region of Saudi Arabia.MethodsThe study retrospectively analysed the antibiograms of wound infections from hospitalized patients for the year 2019. The European Centre for Disease Control guidelines were adopted for the classification of resistant bacteria. Multidrug-, extensive drug-, and carbapenem-resistant isolates are presented as frequencies and percentages.ResultsA total of 295 non-duplicate wound swab antibiograms were retrieved, 64.4% (190) and 35.6% (105) isolates were Gram-negative and Gram-positive bacterial infections respectively. Predominant pathogens included Staphylococcus species 21.0% (62), E. coli 16.3% (48) and K. pneumoniae 13.5% (40). 148 (77.9%), 42 (22.1%) and 43 (22.6%) of the Gram-negative isolates were multidrug-, extensively drug- and carbapenem-resistant. The antibiotic resistance exhibited by gram-negative bacteria was 43.4% (234/539), 59.1% (224/379) and 53.7% (101/188) towards carbapenems, 3rd - and 4th - generation cephalosporins.ConclusionsThe majority of wound infections are caused by multidrug-, extensively drug- and carbapenem-resistant Gram-negative bacteria. Further studies should focus on the molecular basis of this resistance.© 2022 Bandy A et al.

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