• Jing Xiong, Ying Lv, Xu Ma, Guangcong Peng, Chunyi Wu, Jun Hou, Yulan Zhang, Chongyun Wu, Timon Cheng-Yi Liu, and Luodan Yang.
• Collage of Physical Education and Sport Science, South China Normal University, Guangzhou 510006, China; Guangzhou Cadre Health Management Center, Guangzhou 510530, China.
• Neuroscience. 2023 Jul 1; 522: 576857-68.

AbstractRepeated mild traumatic brain injury (rTBI), one of the most common forms of traumatic brain injury, is a worldwide severe public health concern. rTBI induces cumulative neuronal injury, neurological dysfunction, and cognitive deficits. Although there are clinical treatment methods, there is still an urgent need to develop preventive approaches for susceptible populations. Using a repeated closed head injury (rCHI) rat model, we interrogate the effect of sub-lethal hyperthermia preconditioning (SHP) on rCHI-induced neuronal injury and behavioral changes. Our study applied the repeated weight-drop model to induce the rCHI. According to the changes of heat shock protein 70 (HSP 70) in the cortex and hippocampus following a single SHP treatment in normal rats, the SHP was delivered to the rats 18 h before rCHI. We found that HSP significantly alleviated rCHI-induced anxiety-like behaviors and impairments in motor abilities and spatial memory. SHP exerts significant neuroprotection against rCHI-induced neuronal damage, apoptosis, and neuroinflammation. Our findings support the potential use of SHP as a preventative approach for alleviating rCHI-induced brain damage.Copyright © 2023 IBRO. Published by Elsevier Ltd. All rights reserved.

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